Search results for "Single photon emission"
showing 10 items of 14 documents
Evaluation of Mucociliary Clearance by Three Dimension Micro-CT-SPECT in Guinea Pig: Role of Bitter Taste Agonists
2016
Different image techniques have been used to analyze mucociliary clearance (MCC) in humans, but current small animal MCC analysis using in vivo imaging has not been well defined. Bitter taste receptor (T2R) agonists increase ciliary beat frequency (CBF) and cause bronchodilation but their effects in vivo are not well understood. This work analyzes in vivo nasal and bronchial MCC in guinea pig animals using three dimension (3D) microCT-SPECT images and evaluates the effect of T2R agonists. Intranasal macroaggreggates of albumin-Technetium 99 metastable (MAA-Tc99m) and lung nebulized Tc99m albumin nanocolloids were used to analyze the effect of T2R agonists on nasal and bronchial MCC respecti…
Drug Distribution to Retinal Pigment Epithelium: Studies on Melanin Binding, Cellular Kinetics, and Single Photon Emission Computed Tomography/Comput…
2016
Melanin binding is known to affect the distribution and elimination of ocular drugs. The purpose of this study was to evaluate if the extent of drug uptake to primary retinal pigment epithelial (RPE) cells could be estimated based on in vitro binding studies with isolated melanin and evaluate the suitability of single photon emission computed tomography/computed tomography (SPECT/CT) in studying pigment binding in vivo with pigmented and albino rats. Binding of five compounds, basic molecules timolol, chloroquine, and nadolol and acidic molecules methotrexate and 5(6)-carboxy-2',7'-dichlorofluorescein (CDCF), was studied using isolated melanin from porcine choroid-RPE at pH 5.0 and 7.4. The…
Correlation of cerebral blood flow and treatment effects of repetitive transcranial magnetic stimulation in depressed patients.
2002
The aims of this study were to: (1) assess the effects of repetitive transcranial magnetic stimulation (rTMS) on brain activity in depressed patients as measured by single photon emission tomography (SPECT); (2) evaluate the predictive value of brain SPECT on the antidepressant efficacy of rTMS. Patients (n=17) received 1600 rTMS stimuli at a rate of 10 Hz, 5 days per week for 2 weeks to the left dorsolateral prefrontal cortex. Whole brain SPECT data were acquired using Tc99m-Bicisate. Regional cerebral blood flow (rCBF) was correlated with the % change in the 28-item Hamilton Depression Rating Scale Score (Δ-HDRS) and a semiquantitative region of interest (ROI) analysis was conducted. Prio…
The role of combined techniques of scintigraphy and SPECT/CT in the diagnosis of primary hyperparathyroidism
2019
Abstract Rationale: Primary hyperparathyroidism, usually as a result of a hyperfunctioning parathyroid gland, represents more than 90% cases of patients evaluated for hypercalcemia. Combined techniques of preoperative scintigraphy and SPECT/CT serve as a successful minimally-invasive parathyroidectomy. This recent imaging method provides four-dimensional functional images with advanced contrast resolution which greatly facilitates preoperative localization of parathyroid adenomas. Patient concerns: We presented the case of a male Caucasian patient, aged 67 years, who was investigated for hypercalcemia. Increased levels of parathormone, cervical ultrasonography without pathological changes, …
Single Photon Emission from Site-Controlled InAs Quantum Dots Grown on GaAs(001) Patterned Substrates
2009
5 páginas, 5 figuras.
Two-Color Single-Photon Emission from In As Quantum Dots: Toward Logic Information Management Using Quantum Light
2014
In this work, we propose the use of the Hanbury-Brown and Twiss interferometric technique and a switchable two-color excitation method for evaluating the exciton and noncorrelated electron-hole dynamics associated with single photon emission from indium arsenide (InAs) self-assembled quantum dots (QDs). Using a microstate master equation model we demonstrate that our single QDs are described by nonlinear exciton dynamics. The simultaneous detection of two-color, single photon emission from InAs QDs using these nonlinear dynamics was used to design a NOT AND logic transference function. This computational functionality combines the advantages of working with light/photons input/output device…
Timing Control of a Heralded Single Photon Emission
2012
We experimentally demonstrate controlling the emission timing of a heralded single photon from a non-degenerate optical parametric oscillator, by placing another quickly tunable cavity at the exit as a shutter.
First coincidences in pre-clinical Compton camera prototype for medical imaging
2003
Abstract Compton collimated imaging may improve the detection of gamma rays emitted by radioisotopes used in single photon emission computed tomography (SPECT). We present a crude prototype consisting of a single 500 μm thick, 256 pad silicon detector with pad size of 1.4×1.4 mm 2 , combined with a 15×15×1 cm 3 NaI scintillator crystal coupled to a set of 20 photo multipliers. Emphasis is placed on the performance of the silicon detector and the associated read-out electronics, which has so far proved to be the most challenging part of the set-up. Results were obtained using the VATAGP3, 128 channel low-noise self-triggering ASIC as the silicon detector's front-end. The noise distribution (…
High performance 3D CZT spectro-imager for BNCT-SPECT: preliminary characterization
2018
The National Institute of Nuclear Physics (INFN) is supporting the 3CaTS project with the aim of developing a new Single Photon Emission Computed Tomography (SPECT) system for real time 10 B therapeutic dose monitoring in the binary experimental hadron therapy called Boron Neutron Capture Therapy (BNCT). BNCT is a highly selective tumour treatment based on the neutron capture reaction 10 B(n,α) 7 Li. The secondary particles have a high LET with ranges in tissues of the order of 10 μm (thus less than the mean cell diameter of few tens μm). Targeting the 10 B delivery towards cancer, the released energy lethally damages only the malignant cells sparing the normal tissues, thus enabling a cell…
Intraoperative Scintigraphy With Portable Gamma Camera for the Localization of Interaortocaval Paraganglioma
2021
A 15-year-old adolescent girl diagnosed of interaortocaval paraganglioma with a positive 123I-MIGB SPECT/CT and 1 unsuccessful prior surgery was operated on with the assistance of a handheld gamma camera. Once the lesion was located and removed, 2 images were taken, one of the surgical field (without 123I-MIGB uptake) and another of the tumor ex vivo (with high 123I-MIGB uptake), confirming that the lesion had been satisfactorily excised. This case highlights the use of a portable gamma camera as a useful tool to locate this rare tumor, with a SPECT/CT positive for 123I-MIGB and a difficult anatomical location suspected.